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KMID : 0387820160230010061
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Clinical Pediatric Hematology-Oncology
2016 Volume.23 No. 1 p.61 ~ p.64
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A Case of Diffuse Neonatal Hemangiomatosis Successfully Treated with Propranolol
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Jeong Seung-Yeon
Lee Mee-Jeong
Yu Jee-Suk
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Abstract
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We present a case of a 41-day-old girl with diffuse hemangiomatosis on her chin, right thigh, occipital area, and liver. She also had hepatomegaly, heart failure, and hypothy-roidism. Hemangiomatosis did not respond to 2 weeks of oral administration of pre-dnisolone, but was successfully treated with propranolol. After 2 years of propranolol treatment, the lesions of hemangiomatosis nearly disappeared. Hypothyroidism was con-trolled by levothyroxine replacement. As hemangiomatosis regressed, thyroid function was normalized. Propranolol may have adverse effects including hypotension, hypo-glycemia, bronchoconstriction, and restlessness, but she did not experience such adverse effects. Propranolol could be the first choice for diffuse neonatal hemangiomatosis (DNH). Our case also suggests that thyroid function test is needed in patient with DNH.
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KEYWORD
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Diffuse neonatal hemangiomatosis, Propranolol, Liver hemangioma
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